What is the mortality rate associated with Legionella pneumophilia infections?

Legionella pneumophila, the bacterium responsible for Legionnaires' disease, is associated with significant morbidity and mortality, particularly among susceptible populations such as the elderly, smokers, and individuals with compromised immune systems. The mortality rate for untreated Legionnaires' disease has been reported to be as high as 40%, highlighting the severe health risks posed by these infections.

Additionally, factors such as the patient's age, underlying health conditions, and the promptness of treatment initiation can influence mortality rates. However, studies and clinical data consistently indicate that when the disease progresses without timely and appropriate intervention, the higher end of the mortality spectrum, approaching 40%, is observed. Therefore, recognizing the severity of Legionella infections and their associated mortality rates informs public health responses and clinical management strategies.